Description
The plasma membranes of mammalian cells are formed from phosphorlipids, eg. cardiolipin (important component of the inner mitochondrial membrane). Phospholipid antibodies occur in patients with a variety of clinical signs and symptoms notably pregnancy morbidity, antiphospholipid syndrome (Hughes syndrome), livedoid vasculitis, vertebrobasilar insufficiency, Behçet’s syndrome, thrombosis, unexplained cutaneous circulation disturbances (livido reticularis or pyoderma gangrenosum), thrombocytopenia, hemolytic anemia and nonbacterial thrombotic endocarditis and systemic lupus erythematosus (SLE).
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