Determination of blood urea nitrogen is the most widely used screening test for renal function. When used in conjunction with serum creatinine determinations it can aid in the differential diagnosis of the three types of azotemia: prerenal, renal, and postrenal.
Elevations in blood urea nitrogen concentration are seen in inadequate renal perfusion, shock, diminished blood volume (prerenal causes), chronic nephritis, nephrosclerosis, tubular necrosis, glomerular-nephritis (renal causes), and urinary tract obstruction (postrenal causes).
Transient elevations may also be seen during periods of high protein intake. Unpredictable levels occur with liver diseases.
