Aluminium

Quantitative determination of aluminium is used for monitoring for aluminium toxicity in patients undergoing dialysis, routine aluminium screening and monitoring metallic prosthetic implant wear.

Patients with renal failure (RF) lose the ability to clear aluminium and can accumulate aluminium in brain and bones.

Brain deposition has been implicated as a cause of dialysis dementia. In bone, aluminium replaces calcium at the mineralization front, disrupting normal osteoid formation.